1951, U.S. student slang, probably an alteration of 1940s slang nert "stupid or crazy person," itself an alteration of nut. The word turns up in a Dr. Seuss book from 1950 ("If I Ran the Zoo"), which may have contributed to its rise.
nepotism
Neptune
Neptunian
neptunium
*ner-
nerd
nerdy
Nereid
nerf
neritic
Nero