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nettlesome (adj.)

"irritable," 1766, from nettle (n.) + -some (1).

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Definitions of nettlesome from WordNet

nettlesome (adj.)
causing irritation or annoyance;
nettlesome paperwork
Synonyms: annoying / bothersome / galling / irritating / pesky / pestering / pestiferous / plaguy / plaguey / teasing / vexatious / vexing
From wordnet.princeton.edu