"basic facts of a situation or problem," by 1961, knitty-gritty, American English, said to have been chiefly used by black jazz musicians, perhaps ultimately from nit and grits "finely ground corn." As an adjective from 1966.
nitro-
nitrogen
nitroglycerine
nitrous
nitty
nitty-gritty
nitwit
niveous
nix
nixie
Nixon