c. 1400, "injury, hurt, harm," from Anglo-French nusaunce, Old French nuisance "harm, wrong, damage," from past-participle stem of nuire "to harm," from Latin nocere "to hurt" (from PIE root *nek- (1) "death"). Sense has softened over time, to "anything obnoxious to a community" (bad smells, pests, eyesores), 1660s, then "source of annoyance, something personally disagreeable" (1831). Applied to persons from 1690s. As an adjective by 1889; the older adjective nuisant was always rare and now is obsolete.