1520s, "sudden paroxysm of physical pain, acute painful spasm," a word of unknown origin, not found in Middle English. Perhaps it is related to prong (prongys of deth is recorded from mid-15c.). Reference to mental or emotional pain is from 1560s. As a verb, "cause or suffer a pang or pangs," c. 1500. Related: Pangs.
pangs of regret
a pang of conscience
panelling
panem et circenses
panettone
pan-European
panfish
pang
Pangaea
pan-German
Panglossian
pangolin
panhandle