"a pouring through, a causing to permeate," 1570s, from Middle French perfusion and directly from Latin perfusionem (nominative perfusio) "a pouring over," noun of action from past participle stem of perfundere "pour out," from per "throughout" (from PIE root *per- (1) "forward," hence "through") + fundere "to pour" (from nasalized form of PIE root *gheu- "to pour").
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