1808 (pernicktie, in Jamieson), of persons, "precise; fastidious; fussily particular, especially about trifles," an extended form of Scottish pernicky, which is of uncertain origin, perhaps somehow from particular. "Association with the knick group of words ... may have been vaguely present" [OED].
permutate
permutation
permute
pern
pernicious
pernickety
perorate
peroration
peroxide
perp
perpendicular