"gout in the foot" (hence gout, generally), late 14c., from Latin podagra, from Greek podagra "gout in the feet," from pod-, stem of pous "foot" (from PIE root *ped- "foot") + agra "a catching, seizure," related to agrein "to take, seize."
pocket-knife
pock-mark
poco
Pocono
pod
podagra
podcast
podgy
podiatry
podium
Podunk