1590s, "disturbance, commotion," a word of unknown origin. Meaning "mental trouble" is from 1640s; verb sense of "to fluster" is attested from 1690s. According to OED originally rhyming with other, brother; the pronunciation shift came in 19c. by influence of bother.
potentiality
potentially
potentiate
potentiometer
pothead
pother
pot-holder
pothole
pot-hook
pot-hunter
*poti-