1704, "small feathery ball (of swansdown, etc.) for applying powder to the skin," from powder (n.) + puff (n.). As a symbol of femaleness or effeminacy, by 1930s.
powder-puff baseball
a powder-puff football game
poverty
POW
pow
powder
powder-horn
powder-puff
powdery
power
power-broker
powerful
power-house