"a comedy fall," by 1930, said to be a word from burlesque or vaudeville theater, from prat "buttock" + fall (n.). "Chiefly N. Amer. slang" [OED]. As a verb from 1940.
prank
prankster
praseodymium
prat
prate
pratfall
Pratt
prattle
pravity
prawn
praxis