1740 in music terms, "first, principal," from Italian primo "first, chief," from Latin primus "first" (see prime (adj.)). As slang for "excellent, first-class," perhaps an elaboration of prime (see O). Of drugs, by 1990s, street slang.
primigravida
priming
primipara
primitive
primitivism
primo
primogenitor
primogeniture
primordial
primp
primrose