1530s, variant of quippy in same sense (1510s), perhaps from Latin quippe "indeed, of course, as you see, naturally, obviously" (used sarcastically), from quid "what" (neuter of pronoun quis "who," from PIE root *kwo-, stem of relative and interrogative pronouns), and compare quibble (n.)) + emphatic particle -pe.
quip (v.)
"make a quip," 1570s, from quip (n.). Related: Quipped; quipping.
quintile
quintillion
quintuple
quintuplet
quinzane
quip
quipu
quire
Quirinal
quirk
quirky