1590s, "cross-shaft," from Latin radius "staff, stake, rod; spoke of a wheel; ray of light, beam of light; radius of a circle," of unknown origin. Perhaps related to radix "root," but de Vaan finds that "unlikely."
The geometric sense first recorded 1610s. Plural is radii. Meaning "circular area of defined distance around some place" is attested from 1953. Meaning "shorter bone of the forearm" is from 1610s in English (the Latin word had been used thus by the Romans).