1530s, back-formation from refrigeration, or else from Latin refrigeratus, past participle of refrigerare "make cool or cold." Related: Refrigerated; refrigerating. Earlier words in the same sense of "to make cold, to cool" were infrigiden, infrigidate (both early 15c.).
many foods must be refrigerated or else they will spoil
refrigerate this medicine
refrangible
refresh
refreshing
refreshment
refrigerant
refrigerate
refrigeration
refrigerator
refry
reft
refuel