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Rome

capital of Italy; seat of an ancient republic and empire; city of the Papacy, Old English, from Old French Rome, from Latin Roma, a word of uncertain origin. "The original Roma quadrata was the fortified enclosure on the Palatine hill," according to Tucker, who finds "no probability" in derivation from *sreu- "flow," and suggests the name is "most probably" from *urobsma (urbs, robur) and otherwise, "but less likely" from *urosma "hill" (compare Sanskrit varsman- "height, point," Lithuanian viršus "upper"). Another suggestion [Klein] is that it is from Etruscan (compare Rumon, former name of Tiber River).

Common in proverbs, such as Rome was not buylt in one daye (1540s); for when a man doth to Rome come, he must do as there is done (1590s); All roads alike conduct to Rome (1806).

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Definitions of Rome from WordNet

Rome (n.)
capital and largest city of Italy; on the Tiber; seat of the Roman Catholic Church; formerly the capital of the Roman Republic and the Roman Empire;
Synonyms: Roma / Eternal City / Italian capital / capital of Italy
Rome (n.)
the leadership of the Roman Catholic Church;
From wordnet.princeton.edu