"eccentric person," 1933, U.S. slang, earlier as a type of erratic baseball pitch (1928), from a still earlier name for a type of delivery in cricket (1866), from screw (n.) + ball (n.1). Screwball comedy is attested from 1937, in reference to the work of Carole Lombard.
a screwball proposal without a prayer of working
screen
screenplay
screenshot
screenwriter
screw
screwball
screwdriver
screwy
scribble
scribbler
scribe