1660s, "suited to old age," from French sénile (16c.), from Latin senilis "of old age," from senex (genitive senis) "old, old man," from PIE root *sen- "old." Meaning "weak or infirm from age" is first attested 1848.
Senegal
senescence
senescent
seneschal
senicide
senile
senility
senior
seniority
senna
sennight