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sir

c. 1300, title of honor of a knight or baronet (until 17c. also a title of priests), variant of sire, originally used only in unstressed position. Generalized as a respectful form of address by mid-14c.; used as a salutation at the beginning of letters from early 15c. Not an acronym of anything.

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Definitions of sir from WordNet
1
sir (n.)
term of address for a man;
2
Sir (n.)
a title used before the name of knight or baronet;
From wordnet.princeton.edu