1846, "sister," extended form of sis (q.v.). Meaning "effeminate man" is recorded from 1887; the adjective in this sense is from 1891. Related: Sissiness. Sissy bar is recorded from 1969.
-sis
sis
sisal
sis-boom-bah
sissify
sissy
sist
sister
sisterhood
sister-in-law
sisterly
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