"powdered tobacco to be inhaled," 1680s, from Dutch or Flemish snuf, shortened form of snuftabak "snuff tobacco," from snuffen "to sniff, snuff" (see snuff (v.2)). The practice became fashionable in England c. 1680. Slang phrase up to snuff "knowing, sharp, wide-awake, not likely to be deceived" is from 1811; the exact sense is obscure unless it refers to the "elevating" properties of snuff.