"saliva, spit," late 15c., probably an alteration (by influence of spit (n.1)) of Old English spætl, spatl, from Proto-Germanic *spait- (source also of Old English spætan "to spit"), from PIE root *sp(y)eu- "to spew, spit" (see spew (v.)).
Spitalfields
spitball
spite
spiteful
spitfire
spittle
spittoon
Spitz
spiv
splanchnic
splanchno-