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stubborn (adj.)

late 14c., of uncertain origin. Earliest form is stiborn. OED, Liberman doubt any connection with stub (n.). Related: Stubbornly; stubbornness.

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Definitions of stubborn from WordNet

stubborn (adj.)
tenaciously unwilling or marked by tenacious unwillingness to yield;
Synonyms: obstinate / unregenerate
stubborn (adj.)
not responding to treatment;
stubborn rust stains
a stubborn infection
Synonyms: refractory
From wordnet.princeton.edu