1520s, from Middle French suprême (15c.) and directly from Latin supremus "highest," superlative of superus "situated above," from super "above" (from PIE root *uper "over"). Supreme Being "God" first attested 1690s; Supreme Court is from 1689.
a supreme endeavor
supreme among musicians
supreme courage
the supreme sacrifice
the supreme judgment
a supreme tribunal
the supreme confidence of youth
supreme folly
supralapsarian
supra-national
supra-nationalism
supremacist
supremacy
supreme
supremist
sur-
sura
surcease
surcharge