"easily tickled," 1590s, from tickle + -ish. Literal sense is attested later than the figurative sense "easy to upset" (1580s). An earlier word for this was tickly (1520s). Meaning "difficult to do, dubious, requiring great care" is from 1590s. Related: Ticklishly; ticklishness.
hesitates to be explicit on so ticklish a matter
ticker
ticket
ticking
tickle
tickled
ticklish
tick-tack-toe
ticky-tacky
Ticonderoga
tidal
tidbit