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tilde (n.)

1864, from Spanish, metathesis of Catalan title, from vernacular form of Medieval Latin titulus "stroke over an abridged word to indicate missing letters," a specialized sense of Latin titulus, literally "inscription, heading" (see title (n.)). The mark itself represents an -n- and was used in Medieval Latin manuscripts in an abridged word over a preceding letter to indicate a missing -n- and save space.

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Definitions of tilde from WordNet

tilde (n.)
a diacritical mark (~) placed over the letter n in Spanish to indicate a palatal nasal sound or over a vowel in Portuguese to indicate nasalization;
From wordnet.princeton.edu