1510s, "a single volume of a multi-volume work," from Middle French tome (16c.), from Latin tomus "section of a book, tome," from Greek tomos "volume, section of a book," originally "a section, piece cut off," from temnein "to cut," from PIE root *tem- "to cut." Sense of "a large book" is attested from 1570s.
tombola
tombolo
tomboy
tombstone
tomcat
tome
tom-fool
tomfoolery
Tommy
tommyrot
tomography