an improved kind of trepan, 1620s, from French trephine, which is said to be from Latin tres fines "three ends," but perhaps rather an arbitrary diminutive of trepan. As a verb from 1804. Related: Trephining; trephination.
trendy
Trent
Trenton
*trep-
trepan
trephine
trepid
trepidation
tres
trespass
tress