"small pincers, diminutive tongs," 1650s, extended from tweezes, plural of tweeze "case for tweezers" (1620s), a shortening of etweese, considered as plural of etwee (1610s) "a small case," from French étui "small case" (see etui). Sense transferred from the case to the implement inside it. For form, compare trousers from trouzes.