Old English unclæne, "morally impure, defiled, unfit for food," from un- (1) "not" + clean (adj.). Literal sense of "dirty" is recorded from mid-13c.
wore an unclean shirt
unclean meat
unclasp
unclassified
uncle
Uncle Sam
Uncle Tom
unclean
uncleanly
uncleanness
unclear
uncleared
unclog