1530s, "unjust, unfair," from un- (1) "not" + equal (adj.). Meaning "not the same in amount, size, quality, etc." is recorded from 1560s (inequal in this sense is from late 14c.). Sense of "inadequate, insufficient" (to some task) is attested from 1690s. Related: Unequally.
she was unequal to the task
unendurable
un-English
unenlightened
unenthusiastic
unenviable
unequal
unequivocal
unerring
UNESCO
unethical
uneven