1610s, from up + hill (n.). As an adverb from c. 1600. Grose's "Dictionary of the Vulgar Tongue" (1785) has "Uphills, false dice that run high."
she was talking uphill
this street lay uphill
upfront
upgather
upgrade
upheaval
upheld
uphill
uphold
upholster
upholsterer
upholstery
upkeep