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vexation (n.)

c. 1400, from Old French vexacion "abuse, harassment; insult, affront," or directly from Latin vexationem (nominative vexatio) "annoyance, harassing; distress, trouble," noun of action from past participle stem of vexare "to harass, trouble" (see vex).

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Definitions of vexation from WordNet

vexation (n.)
anger produced by some annoying irritation;
Synonyms: annoyance / chafe
vexation (n.)
the psychological state of being irritated or annoyed;
vexation (n.)
something or someone that causes anxiety; a source of unhappiness;
Synonyms: concern / worry / headache
vexation (n.)
the act of troubling or annoying someone;
From wordnet.princeton.edu