also wheelhouse, 1835, "structure enclosing a large wheel," especially one over the steering wheel of a steamboat, thus "pilot house;" from wheel (n.) + house (n.). Baseball slang sense of "a hitter's power zone" attested by 1990.
whee
wheedle
wheel
wheelbarrow
wheelchair
wheel-house
wheelie
wheelwright
wheeze
wheezy
whelk