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See also:BERBERINE, CBH17NO4 , an See also:alkaloid occurring together with the alkaloids oxyacanthine C16H19NO3, berbamine C13H19NO3, See also:hydrastine C21H21N06, and canadine C20H21NO4, in Berberis vulgaris; it also occurs in other See also:plants, Berberis aristata, B. aquifolium, Hydrastis canadensis, &c. It is a yellow, crystalline solid, insoluble in See also:ether and See also:chloroform, soluble in 41 parts of See also:water at 2 1°, and moderately soluble in See also:alcohol. It is a monacid See also:base; the hydrochloride, C2BH17NO4•HCI, is insoluble in See also:cold alcohol, ether and chloroform, and soluble in 500 parts of water; the See also:acid sulphate, C20H17N04•112SO4, dissolves in about See also:loo parts of water. Canadine is a tetrahydroberberine. Its constitution was worked out by W. H. See also:Perkin (J.C.S., 1889, 55, p. 63; 189o, 57, p. 991). This followed from a study of the decomposition products, there being obtained hemipinic acid (CH3O)2C6H2(000H)2, and a substance which proved to be to- amino -See also:ethyl- piperonyl carboxylic acid, CH2O2:C6H2•COOH•CH2•CH2NH2. His See also:formula was modified by Gadamer (Abs. J.C.S., 1902, I, p. 555), who made the See also:free base an aldehyde, but the salts of an iso-quinolinium type. This formula, which necessitates the presence of two See also:asymmetric See also:carbon atoms in an alkyl tetrahydroberberine, has been accepted by M. See also:Freund and F. See also:Mayer (Abs. J.C.S., 1907, I, p. 632), who showed that two racemic propyl tetrahydroberberines are produced when propyl dihydroberberine is reduced. Additional information and CommentsThere are no comments yet for this article.
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