word-forming element meaning "deputy, assistant, substitute," also "instead of, in place of," 15c., from Latin vice "in place of," ablative of vicis "a change, a turn, interchange alternation" (from PIE root *weik- (2) "to bend, to wind"). In Middle English sometimes borrowed in Old French form vis-, vi-.

short for venereal disease (see venereal), by 1916 in medical publications.