before vowels, gluc-, word-forming element used since c. 1880s, a later form of glyco-, from Greek glykys "sweet," figuratively "delightful; dear; simple, silly," from *glku-, a dissimilation in Greek from PIE root *dlk-u- "sweet" (source also of Latin dulcis). De Vaan writes that "It is likely that we are dealing with a common borrowing from an unknown source." Now usually with reference to glucose.