"white crystalline alkaloid present in opium," 1838, codeina, from French codéine, coined, with chemical suffix -ine (2), from Greek kodeia "poppy head," related to koos "prison," literally "hollow place;" kodon "bell, mouth of a trumpet;" koilos "hollow, hollowed out, spacious, deep," all from PIE root *keue- "to swell," also "vault, hole." Modern form is from 1881.
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