"deprive of inhabitants," 1540s; see de- + populate. Perhaps from Latin depopulatus, past participle of depopulari "to lay waste, ravage." Related: Depopulated; depopulating. Earlier in same sense was dispeplen (early 15c.).
The epidemic depopulated the countryside
deploy
deployment
depolarization
depoliticize
deponent
depopulate
depopulation
deport
deportation
deportee
deportment
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