c. 1300, "a soreness of the eyes" (obsolete); modern sense of "something offensive to the eye" is from 1520s; from eye (n.) + sore (n.). In the sense "eye disease" Old English had eagseoung.
eye-service
eye-shade
eye-shadow
eye-shot
eyesight
eyesore
eye-tooth
eyewash
eye-witness
eyot
eyrie