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sore (adj.)

Old English sar "painful, grievous, aching, sad, wounding," influenced in meaning by Old Norse sarr "sore, wounded," from Proto-Germanic *saira- "suffering, sick, ill" (source also of Old Frisian sar "painful," Middle Dutch seer, Dutch zeer "sore, ache," Old High German ser "painful," Gothic sair "pain, sorrow, travail"), from PIE root *sai- (1) "suffering" (source also of Old Irish saeth "pain, sickness").

Adverbial use (as in sore afraid) is from Old English sare but has mostly died out (replaced by sorely), but remains the main meaning of German cognate sehr "very." Slang meaning "angry, irritated" is first recorded 1738.

sore (n.)

Old English sar "bodily pain or injury, wound; sickness, disease; state of pain or suffering," from root of sore (adj.). Now restricted to ulcers, boils, blisters. Compare Old Saxon ser "pain, wound," Middle Dutch seer, Dutch zeer, Old High German ser, Old Norse sar, Gothic sair.

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Definitions of sore from WordNet
1
sore (adj.)
hurting;
Synonyms: sensitive / raw / tender
sore (adj.)
causing misery or pain or distress;
it was a sore trial to him
Synonyms: afflictive / painful
sore (adj.)
roused to anger; "stayed huffy a good while"- Mark Twain;
sore over a remark
Synonyms: huffy / mad
2
sore (n.)
an open skin infection;
From wordnet.princeton.edu