1520s, "put heart into" (transitive), from heart (n.) in the figurative sense + -en (1). Intransitive sense "to cheer up" is from 1708. Related: Heartened; heartening. Earlier verb was simply heart (Old English).
heartbreak
heart-breaker
heartbroken
heartburn
-hearted
hearten
heart-felt
heartful
hearth
heartily
heartland