1796, "having keys," from key (n.) in the musical sense. Also "to set the tone (of a musical instrument) to a particular key; hence figurative keyed up "excited, high-strung" (1889).
a keyed instrument
the locks have not yet been keyed
kewpie
kex
key
keyboard
keychain
keyed
keyhole
keyless
Keynesian
keynote
keypad