late 14c., "state of grievous affliction, condition of external unhappiness," from Old French misere "miserable situation, misfortune, distress" (12c.), from Latin miseria "wretchedness," from miser "wretched, pitiable" (see miser). Meaning "condition of one in great sorrow or mental distress" is from 1530s.
the misery and wretchedness of those slums is intolerable
she was exhausted by her misery and grief
miser
miserable
miserably
Miserere
miserly
misery
misestimate
misfeasance
misfield
misfire
misfit