1900 in the biological sense, "individual or form which has arisen by or undergone (genetic) mutation," from Latin mutantem (nominative mutans) "changing," present participle of mutare "to change" (from PIE root *mei- (1) "to change, go, move"). In the science fiction sense, it is attested by 1954. As an adjective from 1903.
a mutant gene
mustn't
musty
mutability
mutable
mutagen
mutant
mutate
mutation
mutatis mutandis
mute
muted