"small, tailed, salamander-like amphibian," early 15c., neute, newte, a misdivision of an ewte (see N for other examples), a variation of Middle English evete (see eft). "Eft, though now only provincial, is strictly the correct form" [Century Dictionary]. OED notes that "the change of v to w is unusual."
newsreel
newsroom
news-stand
newsworthy
newsy
newt
Newton
next
next-door
nexus
Nez Perce