1883, "having the nature or character of snakes or serpents," from Greek ophidion, diminutive of ophis "serpent" (see ophio-). Earlier in zoology, "belonging to the order Ophidia" (comprising snakes, serpents), 1819. As a noun, "reptile of the order Ophidia," from 1819.
operator
operculum
operetta
operose
Ophelia
ophidian
ophidiophobia
ophio-
ophiomancy
ophiophagous
Ophir