1914, "excessive fear of snakes or reptiles," from ophidio- apparently extracted from Modern Latin ophidia, a word coined arbitrarily (to provide an -ia form to serve as an order name in taxonomy) from Greek ophis "serpent" (see ophio-) + -phobia.
operculum
operetta
operose
Ophelia
ophidian
ophidiophobia
ophio-
ophiomancy
ophiophagous
Ophir
Ophiuchus