"medicine containing opium," early 15c., from Medieval Latin opiatus, from Latin opium (see opium). Figurative sense of "anything that dulls the feelings and induces rest or inaction" is from 1640s. From 1540s in English as an adjective, "made with or containing opium," hence "inducing sleep, narcotic."
ophthalmic
ophthalmo-
ophthalmologist
ophthalmology
ophthalmoscope
opiate
opine
opiniaster
opiniated
opinion
opinionate