"four-sided," 1640s, with -al (1) + Latin quadrilaterus, from quadri- "four" (from PIE root *kwetwer- "four") + latus (genitive lateris) "the side, flank of humans or animals, lateral surface," a word of uncertain origin. As an adjective from 1650s. Related: Quadrilaterally.
quadri-
quadricentennial
quadricep
quadriceps
quadrifid
quadrilateral
quadriliteral
quadrille
quadrillion
quadripartite
quadriplegia